DNA nanotechnology in molecular design of thrombin aptamers
نویسندگان
چکیده
منابع مشابه
Nanotechnology and aptamers: applications in drug delivery.
Nucleic acid ligands, also known as aptamers, are a class of macromolecules that are being used in several novel nanobiomedical applications. Aptamers are characterized by high affinity and specificity for their target, a versatile selection process, ease of chemical synthesis and a small physical size, which collectively make them attractive molecules for targeting diseases or as therapeutics....
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متن کاملThrough-bond effects in the ternary complexes of thrombin sandwiched by two DNA aptamers
Aptamers directed against human thrombin can selectively bind to two different exosites on the protein surface. The simultaneous use of two DNA aptamers, HD1 and HD22, directed to exosite I and exosite II respectively, is a very powerful approach to exploit their combined affinity. Indeed, strategies to link HD1 and HD22 together have been proposed in order to create a single bivalent molecule ...
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A series of DNA aptamers bearing triazole internucleotide linkages that bind to thrombin was synthesized. The novel aptamers are structurally analogous to the well-known thrombin-inhibiting G-quadruplexes TBA15 and TBA31. The secondary structure stability, binding affinity for thrombin and anticoagulant effects of the triazole-modified aptamers were measured. A modification in the central loop ...
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ژورنال
عنوان ژورنال: Chinese Science Bulletin
سال: 2018
ISSN: 0023-074X
DOI: 10.1360/n972018-00882